Premium
Back Cover: Effective Amyloid Defibrillation by Polyhydroxyl‐Substituted Squaraine Dyes (Chem. Asian J. 12/2015)
Author(s) -
Jayaram Dhanya T.,
Shankar Balaraman H.,
Ramaiah Danaboyina
Publication year - 2015
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201501124
Subject(s) - chemistry , amyloid (mycology) , lysozyme , biophysics , combinatorial chemistry , photochemistry , polymer chemistry , biochemistry , biology , inorganic chemistry
Water‐soluble near‐infrared (NIR)‐absorbing squaraine dyes were found to exhibit strong interactions with lysozyme and β‐amyloids. The effective interactions resulted in the complete disassembly of the β‐amyloid fibrillar structures to form spherical shaped particles. Accordingly, the results demonstrate the potential of the dyes for efficient protein labelling and as inhibiting agents of protein amyloidogenesis. More information can be found in the Full Paper by Danaboyina Ramaiah et al. (DOI: 10.1002/asia.201500780).