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Inside Cover: Chimeric RNA Oligonucleotides with Triazole and Phosphate Linkages: Synthesis and RNA Interference (Chem. Asian J. 12/2015)
Author(s) -
Fujino Tomoko,
Kogashi Kanako,
Okada Koudai,
Mattarella Martin,
Suzuki Takeru,
Yasumoto Kenichi,
Sogawa Kazuhiro,
Isobe Hiroyuki
Publication year - 2015
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201501122
Subject(s) - phosphoramidite , oligonucleotide , rna , solid phase synthesis , rna interference , combinatorial chemistry , chemistry , triazole , click chemistry , aptamer , computational biology , biology , biochemistry , microbiology and biotechnology , dna , gene , organic chemistry , peptide
A triazole linkage embedded in a 21‐mer RNA oligonucleotide has been favorably accepted by the Argonaute protein for RNA interference. Researchers at Tohoku University now report structure–activity relationship studies with a series of chimeric oligonucleotides. Their robust synthesis is backed up by a combination of click chemistry and solid‐phase phosphoramidite synthesis, which enables the synthesis of chimeric oligonucleotides of any given sequence possessing triazole linkages at any desired positions. More information can be found in the Full Paper by Hiroyuki Isobe et al. (DOI: 10.1002/asia.201500765).