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Cover Picture: Differential Effects of Polymer‐Surface Decoration on Drug Delivery, Cellular Retention, and Action Mechanisms of Functionalized Mesoporous Silica Nanoparticles (Chem. Asian J. 12/2015)
Author(s) -
You Yuanyuan,
Hu Hao,
He Lizhen,
Chen Tianfeng
Publication year - 2015
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201501121
Subject(s) - mesoporous silica , nanoparticle , drug delivery , cover (algebra) , nanotechnology , mesoporous material , polymer , materials science , surface modification , chemical engineering , chemistry , organic chemistry , composite material , engineering , mechanical engineering , catalysis
Different polymers linked with a cancer‐targeting ligand Arg‐Gly‐Asp (RGD) peptide have been used to decorate mesoporous silica nanoparticles (MSNs), and the functionalized nanosystems were used as drug carriers of oxaliplatin (OXA). Poly(ethylene glycol) (PEG) and polyethyleneimine (PEI) functionalization significantly enhanced the anticancer efficacy of the loaded drug by increasing the cellular uptake and cellular drug retention. PEI@MSNs‐OXA possessed excellent penetrating ability and inhibitory effects on SW480 cancer cells. Therefore, this study provides useful information for the rational design of cancer‐targeting MSN systems with polymer surface decoration. More information can be found in the Full Paper on page 2744 by Tianfeng Chen et al. (DOI: 10.1002/asia.201500769).