BODIPY/Nile‐Red‐Based Efficient FRET Pair: Selective Assay of Endoplasmic Reticulum Membrane Fluidity | Zendy

Yang Zhigang | Zendy; Wi Youngjin | Zendy; Yoon YoungMin | Zendy; Verwilst Peter | Zendy; Jang Joo Hee | Zendy; Kim Tae Woo | Zendy; Kang Chulhun | Zendy; Kim Jong Seung | Zendy

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BODIPY/Nile‐Red‐Based Efficient FRET Pair: Selective Assay of Endoplasmic Reticulum Membrane Fluidity

Author(s) -

Yang Zhigang,

Wi Youngjin,

Yoon YoungMin,

Verwilst Peter,

Jang Joo Hee,

Kim Tae Woo,

Kang Chulhun,

Kim Jong Seung

Publication year - 2016

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201501060

Subject(s) - endoplasmic reticulum , nile red , bodipy , membrane fluidity , förster resonance energy transfer , chemistry , membrane , moiety , biophysics , red blood cell , microsome , biochemistry , microbiology and biotechnology , fluorescence , biology , stereochemistry , physics , quantum mechanics , enzyme

We synthesized a boron‐dipyrromethene (BODIPY)/Nile Red hybrid probe capable of selectively recognizing fluidity changes in the endoplasmic reticulum (ER) membrane due to its preferential localization to the ER and strong energy transfer from BODIPY to the Nile Red moiety, emitting only in nonaqueous environments. ER membrane fluidity in HepG2 cells was markedly reduced by a cell model of metabolic syndrome.

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