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HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery
Author(s) -
Lee Hoyeon,
Uhm Soojin,
Shin JungWon,
Jeon Hyun Mi,
Dongbang Sun,
Jung Hyo Sung,
Na YunCheol,
Kang Chulhun,
Kim Jong Seung
Publication year - 2015
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201500913
Subject(s) - camptothecin , prodrug , drug , drug resistance , drug delivery , pharmacology , chemistry , sn 38 , cell , biology , medicine , biochemistry , irinotecan , microbiology and biotechnology , cancer , colorectal cancer , organic chemistry
A galactose‐appended drug delivery system released camptothecin (CPT) to lysosomes of HepG2 hepatoma cells, resulting in the cell resistance to the anticancer drug. We found that the resistance to CPT is caused by alteration of the drug release from the prodrug in lysosomes, emphasizing that the final delivery locations may critically influence drug efficacy.