Premium
Rhodium‐catalyzed Asymmetric Hydrogenation of α‐Dehydroamino Ketones: A General Approach to Chiral α‐amino Ketones
Author(s) -
Gao Wenchao,
Wang Qingli,
Xie Yun,
Lv Hui,
Zhang Xumu
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201500892
Subject(s) - rhodium , asymmetric hydrogenation , catalysis , noyori asymmetric hydrogenation , chemistry , ketone , organic chemistry , enantioselective synthesis
Abstract Rhodium/DuanPhos‐catalyzed asymmetric hydrogenation of aliphatic α‐dehydroamino ketones has been achieved and afforded chiral α‐amino ketones in high yields and excellent enantioselectives (up to 99 % ee ), which could be reduced further to chiral β‐amino alcohols by LiAlH( t BuO) 3 with good yields . This protocol provides a readily accessible route for the synthesis of chiral α‐amino ketones and chiral β‐amino alcohols.