Premium
Copper‐Catalyzed Direct Sulfoximination of Heteroaromatic N ‐Oxides by Dual C−H/N−H Dehydrogenative Cross‐Coupling
Author(s) -
Yu Hao,
Dannenberg Carl Albrecht,
Li Zhen,
Bolm Carsten
Publication year - 2016
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201500875
Subject(s) - quinoline , catalysis , reactivity (psychology) , dual (grammatical number) , chemistry , ligand (biochemistry) , combinatorial chemistry , coupling (piping) , base (topology) , copper , medicinal chemistry , dual role , organic chemistry , materials science , mathematics , medicine , art , mathematical analysis , biochemistry , alternative medicine , literature , receptor , pathology , metallurgy
A dual C−H/N−H dehydrogenative coupling of quinoline‐type N ‐oxides with sulfoximines that leads to N ‐(hetero)arylsulfoximines in high yields has been realized by using a catalytic amount of CuBr in air. The method does not require any additional ligand, base, reactivity modifier or oxidant and provides a practical route towards a series of sulfoximidoyl‐functionalized quinolines and derivatives.