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Back Cover: Synthetic and Computational Evaluation of Regiodivergent Epoxide Opening for Diol and Polyol Synthesis (Chem. Asian J. 8/2014)
Author(s) -
Gansäuer Andreas,
Karbaum Peter,
Schmauch David,
Einig Martin,
Shi Lili,
Anoop Anakuthil,
Neese Frank
Publication year - 2014
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201490032
Subject(s) - polyol , epoxide , diol , cover (algebra) , chemistry , stereochemistry , organic chemistry , engineering , catalysis , polyurethane , mechanical engineering
Epoxide Opening Epoxides can be readily synthesized in a highly enantiomerically enriched form by numerous methods, and epoxide openings are attractive substrates for divergent reactions. In their Full Paper on page 2289 ff., featured on the Back Cover, Andreas Gansäuer, Frank Neese et al. have devised a novel concept for the synthesis of 1,2‐, 1,3‐, and 1,4‐diols through regiodivergent epoxide opening (REO). Through a combination of theory and synthesis, suitable substrates for highly selective reactions with Kagan's complex have been identified. The structures and energies of the transition states involved in epoxide opening provide a mechanism‐based platform for designing applications in the synthesis of complex molecules.