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Inside Cover: Construction and DNA Condensation of Cyclodextrin‐Coated Gold Nanoparticles with Anthryl Grafts (Chem. Asian J. 7/2014)
Author(s) -
Zhao Di,
Chen Yong,
Liu Yu
Publication year - 2014
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201490023
Subject(s) - dna condensation , conjugate , condensation , dna , colloidal gold , adamantane , cyclodextrin , supramolecular chemistry , nanoparticle , gene delivery , intercalation (chemistry) , chemistry , macromolecule , combinatorial chemistry , nanotechnology , condensation reaction , polymer chemistry , materials science , crystallography , organic chemistry , genetic enhancement , gene , biochemistry , crystal structure , catalysis , mathematical analysis , transfection , physics , mathematics , thermodynamics
DNA Condensation The condensation of DNA in a controlled manner is one of the key steps in gene delivery and gene therapy. As described in their Full Paper on page 1895 ff., Yu Liu and co‐workers designed and constructed a water‐soluble and nontoxic nanometer‐sized conjugate comprising gold nanoparticles, β‐cyclodextrins, and anthryl adamantanes (see the Inside Cover). This conjugate exhibits a good condensation ability toward DNA through the intercalation of the anthryl groups into the DNA double helix. Significantly, the condensation efficiency of the supramolecular nanostructure towards DNA could be conveniently controlled by adjusting the ratio between gold nanoparticles and anthryl adamantane grafts.