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Cover Picture: Porous Protein Crystals as Catalytic Vessels for Organometallic Complexes (Chem. Asian J. 5/2014)
Author(s) -
Tabe Hiroyasu,
Abe Satoshi,
Hikage Tatsuo,
Kitagawa Susumu,
Ueno Takafumi
Publication year - 2014
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201490012
Subject(s) - catalysis , chemistry , tetragonal crystal system , crystallography , orthorhombic crystal system , protein crystallization , porosity , lysozyme , chemical engineering , organic chemistry , crystal structure , biochemistry , crystallization , engineering
Biohybrid catalysts have been developed by incorporating organometallic complexes into cross‐linked porous protein crystals. As reported by Takafumi Ueno, Susumu Kitagawa et al. in their Full Paper on page 1373 ff., organoruthenium complexes in cross‐linked porous hen egg white lysozyme (HEWL) crystals had an improved catalytic activity of hydrogen transfer reduction of acetophenone derivatives as compared to that of a buffer solution containing the organoruthenium complexes and HEWL. The reaction catalyzed in the tetragonal and orthorhombic HEWL crystals gave different enantiomers by specific protein–substrate interactions. This method represents a new approach for the construction of reaction nanovessels using protein crystals.