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Direct N‐Methylation Reaction Using DMSO as One‐Carbon Bridge: Convenient Access to Heterocycle‐Containing β‐Amino Ketones
Author(s) -
Sun Kai,
Wang Xin,
Jiang Yongqing,
Lv Yunhe,
Zhang Liping,
Xiao Beibei,
Li Donghui,
Zhu Zhonghong,
Liu Lin
Publication year - 2015
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201403358
Subject(s) - chemistry , solvent , methylation , medicinal chemistry , combinatorial chemistry , decomposition , organic chemistry , polymer chemistry , biochemistry , gene
A novel oxidative CS bond cleavage reaction of DMSO for dual CC and CN bond formation is described. A series of acetyl heteroarenes could be selectively converted into the corresponding β‐amino ketones, which are frequently found in biologically active compounds and pharmaceuticals. DMSO acted in this reaction not only as the solvent but also as a one‐carbon bridge.