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Copper‐Catalyzed Enantioselective Conjugate Addition of Grignard Reagents to Methyl 4,4,4‐Trifluorocrotonate: Synthesis of Enantioenriched Trifluoromethylated Compounds
Author(s) -
Zhang LiYing,
Zhou JiaHui,
Xu YunHe,
Loh TeckPeng
Publication year - 2015
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201403303
Subject(s) - enantioselective synthesis , conjugate , chemistry , catalysis , reagent , trifluoromethyl , copper , grignard reagent , addition reaction , organic chemistry , grignard reaction , combinatorial chemistry , medicinal chemistry , alkyl , mathematics , mathematical analysis
Copper‐catalyzed enantioselective 1,4‐conjugate addition of methyl 4,4,4‐trifluorocrotonate with aliphatic Grignard reagents to access an asymmetric tertiary carbon center attached with a trifluoromethyl group was achieved under mild reaction conditions. The desired products could be obtained in reasonable yields and good enantioselectivities.