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Ion and Molecular Recognition Using Aryl–Ethynyl Scaffolding
Author(s) -
Vonnegut Chris L.,
Tresca Blakely W.,
Johnson Darren W.,
Haley Michael M.
Publication year - 2015
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201403212
Subject(s) - scaffold , aryl , ion , chemistry , scaffold protein , computer science , computational biology , combinatorial chemistry , biology , biochemistry , programming language , organic chemistry , alkyl , signal transduction
The aryl–ethynyl linkage has been extensively employed in the construction of hosts for a variety of guests. Uses range from ion detection (e.g., of metal cations in the environment or industrial waste and of anions prevalent in nature), to molecular mimics for biological systems, and to applications targeting future safety issues (such as CO 2 capture and indicators for the manufacture of chemical weapons). This Focus Review examines the utilization of the aryl–ethynyl linkage in engineering host molecules for a variety of different guests, and how the alkyne unit plays an integral part as both a rigid scaffolding section in host geometry design as well as a linker to allow conjugative communication between discrete π‐electron systems.