Premium
Gold Nanorod–Photosensitizer Complex Obtained by Layer‐by‐Layer Method for Photodynamic/Photothermal Therapy In Vitro
Author(s) -
Kim Seung Beom,
Lee Tae Heon,
Yoon Il,
Shim Young Key,
Lee Woo Kyoung
Publication year - 2015
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201403193
Subject(s) - photosensitizer , photothermal therapy , photodynamic therapy , nanorod , singlet oxygen , zeta potential , cationic polymerization , allylamine , materials science , chemistry , photochemistry , nanotechnology , oxygen , polyelectrolyte , organic chemistry , polymer chemistry , nanoparticle , polymer , composite material
Gold nanorod (GNR)–photosensitizer (PS) complex was prepared using anionic PS (sodium salt of purpurin‐18) and cationic poly(allylamine hydrochloride) by layer‐by‐layer method, and was characterized by transmission electron microscopy, UV‐vis spectroscopy, and zeta potential. The GNR–PS complex is a promising agent for synergistic (photothermal and photodynamic) therapy (PTT/PDT), in which PTT generates heat as well as operates the PS release which maximize the following PDT activity. The combined dual therapy, PTT followed by PDT, exhibits a significantly higher photocytotoxicity result based on synergistic effect of hyperthermia from PTT as well as singlet oxygen photogeneration from PDT.