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Copper‐Catalyzed Radical Carbooxygenation: Alkylation and Alkoxylation of Styrenes
Author(s) -
Liao Zhixiong,
Yi Hong,
Li Zheng,
Fan Chao,
Zhang Xu,
Liu Jie,
Deng Zixin,
Lei Aiwen
Publication year - 2015
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201403097
Subject(s) - alkyl , alkylation , halide , catalysis , chemistry , copper , organic chemistry
A simple copper‐catalyzed direct radical carbooxygenation of styrenes is developed utilizing alkyl bromides as radical resources. This catalytic radical difunctionalization accomplishes both alkylation and alkoxylation of styrenes in one pot. A broad range of styrenes and alcohols are well tolerated in this transformation. The EPR experiment shows that alkyl halides could oxidize Cu(I) to Cu(II) in this transformation.