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Multifunctional Carbon Nanohorn Complexes for Cancer Treatment
Author(s) -
Chechetka Svetlana A.,
Pichon Benoit,
Zhang Minfang,
Yudasaka Masako,
BéginColin Sylvie,
Bianco Alberto,
Miyako Eijiro
Publication year - 2015
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201403059
Subject(s) - photothermal therapy , hela , cancer cell , chemistry , surface modification , conjugated system , nanoparticle , biophysics , cell , cancer , nanotechnology , materials science , biochemistry , organic chemistry , biology , polymer , genetics
Multifunctional carbon nanohorn (CNH) complexes were synthesized using oxidized CNH, magnetite (MAG) nanoparticles, and polyethyleneimine (PEI). The ferromagnetic MAG nanoparticles were loaded onto CNH (MAG‐CNH) using iron(II) acetate and subsequent heat treatment. Chemical functionalization of the MAG‐CNH complexes with PEI improved their water‐dispersibility and allowed further conjugation with a fluorophore. The application of an external magnetic field significantly intensified the targeted vectorization of CNH complexes into human cervical cancer (HeLa) cells. Following cell uptake, laser irradiation of the cells showed a significant enhancement in the photothermal effects of CNHs leading to cell death. We have confirmed that the photothermal properties and ferromagnetic characteristics of CNH complexes show efficient cell elimination. The present study is an essential step toward the development of an innovative cancer therapy and a highly sensitive detection of cancer cells at the single‐cell level.