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Practical, Modular, and General Synthesis of 3‐Coumaranones through Gold‐Catalyzed Intermolecular Alkyne Oxidation Strategy
Author(s) -
Shu Chao,
Liu Rongfu,
Liu Shuang,
Li JianQiao,
Yu YongFei,
He Qiao,
Lu Xin,
Ye LongWu
Publication year - 2015
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201403032
Subject(s) - alkyne , intermolecular force , catalysis , natural product , combinatorial chemistry , chemistry , modular design , organic chemistry , molecule , computer science , operating system
A gold‐catalyzed intermolecular alkyne oxidation for the preparation of 3‐coumaranones has been developed. Using 8‐isopropylquinoline N ‐oxides as oxidants, the reactions of o ‐ethynylanisoles afford versatile 3‐coumaranones in moderate to good isolated yields. The synthetic utility of this chemistry is also indicated by the synthesis of the natural product sulfuretin.