Total Syntheses of Lycoposerramine‐V and 5‐ epi ‐Lycoposerramine‐V

Enantioselective total syntheses of lycopodium alkaloids lycoposerramine‐V and 5‐ epi ‐lycoposerramine‐V have been accomplished. Features of the newly established total synthesis include: 1) introduction of the first chiral center with a scalable desymmetrization reaction of an meso ‐anhydride; 2) chemoselective functionalization of a bis‐Weinreb‐amide with Grignard addition; and 3) construction of the multifunctionalized cyclohexanone with a stereoselective intramolecular Michael addition.