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Copper‐Promoted Site‐Selective Acyloxylation of Unactivated C(sp 3 )H Bonds
Author(s) -
Wu Xuesong,
Zhao Yan,
Ge Haibo
Publication year - 2014
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201402510
Subject(s) - chemistry , copper , denticity , ligand (biochemistry) , methylene , surface modification , medicinal chemistry , stereochemistry , organic chemistry , crystal structure , receptor , biochemistry
The site‐selective acyloxylation of aliphatic amides was achieved via a copper‐promoted C(sp 3 )H bond functionalization process directed by a bidentate ligand. The reaction showed a great preference for activating CH bonds of β ‐methyl groups over those of γ ‐methyl and unactivated methylene groups.