Premium
Selenium–Platinum Coordination Compounds as Novel Anticancer Drugs: Selectively Killing Cancer Cells via a Reactive Oxygen Species (ROS)‐Mediated Apoptosis Route
Author(s) -
Zeng Lingwu,
Li Yang,
Li Tianyu,
Cao Wei,
Yi Yu,
Geng Weijia,
Sun Zhiwei,
Xu Huaping
Publication year - 2014
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201402256
Subject(s) - reactive oxygen species , selenium , chemistry , apoptosis , cisplatin , cytotoxicity , platinum , in vivo , cancer cell , x ray photoelectron spectroscopy , biochemistry , in vitro , cancer , organic chemistry , biology , microbiology and biotechnology , chemotherapy , genetics , catalysis , physics , nuclear magnetic resonance
We report the preparation of selenium‐containing platinum‐based anticancer drug EG‐Se/Pt. EG‐Se/Pt was obtained from the coordination of selenium‐containing molecules (EG‐Se) with cisplatin (CDDP). The structure of EG‐Se/Pt was characterized by 1 H and 77 Se NMR spectroscopy, XPS, ESI‐MS, and MALDI‐TOF. In aqueous solution, EG‐Se/Pt self‐assembles to form spherical aggregates. EG‐Se/Pt shows enhanced stability against dilution and high salt concentration compared with EG‐Se. EG‐Se/Pt induces cell apoptosis via reactive oxygen species (ROS), which leads to high selectivity between cancer cells and normal cells in cytotoxicity assays. More importantly, EG‐Se/Pt effectively inhibits tumor growth in vivo in tumor‐bearing mice. It is anticipated that tuning the ROS level through the assembly of selenium‐containing molecules can be a general method to realize anticancer selectivity.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom