Premium
Synthesis of 1,4,7,10‐Tetra‐azacyclododecan‐1,4,7,10‐tetra‐azidoethylacetic Acid (DOTAZA) and Related “Clickable” DOTA Derivatives
Author(s) -
Kriemen Ella,
Ruf Erik,
Behrens Ulrich,
Maison Wolfgang
Publication year - 2014
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201402250
Subject(s) - tetra , dota , chemistry , click chemistry , chelation , combinatorial chemistry , azide , enantiomer , medicinal chemistry , stereochemistry , organic chemistry
Herein, we report the synthesis of two enantiomeric DOTAZA esters and a related DOT3AZA ester. These compounds are tunable analogues of the well‐known chelator DOTA and can be easily functionalized through click chemistry of the side‐chain azide groups. Like DOTA, DOTAZA forms complexes with various di‐ and trivalent metals, as demonstrated in the synthesis and structural analysis of CuDOTAZA and the preparation of GdDOTAZA.