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Peptide p160‐Coated Silica Nanoparticles Applied in Photodynamic Therapy
Author(s) -
Yang Yang,
Wang Anhe,
Jia Yi,
Brezesinski Gerald,
Dai Luru,
Zhao Jie,
Li Junbai
Publication year - 2014
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201402141
Subject(s) - photodynamic therapy , photosensitizer , mesoporous silica , cytotoxicity , peptide , nanoparticle , conjugated system , selectivity , chemistry , nanocomposite , in vitro , materials science , nanotechnology , mesoporous material , organic chemistry , biochemistry , catalysis , polymer
Peptide p160‐conjugated mesoporous silica nanoparticles (MSN) were fabricated and loaded with photosensitizer hypocrellin B (HB). The results indicate that the nanocomposites have better selectivity for cancer cells and higher cytotoxicity in photodynamic therapy in vitro. The nanocomposites can be used as a novel candidate in photodynamic therapy. This may be a general and promising method to modify nanoparticles to improve their cell affinity.