Peptide p160‐Coated Silica Nanoparticles Applied in Photodynamic Therapy | Zendy

Yang Yang | Zendy; Wang Anhe | Zendy; Jia Yi | Zendy; Brezesinski Gerald | Zendy; Dai Luru | Zendy; Zhao Jie | Zendy; Li Junbai | Zendy

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Peptide p160‐Coated Silica Nanoparticles Applied in Photodynamic Therapy

Author(s) -

Yang Yang,

Wang Anhe,

Jia Yi,

Brezesinski Gerald,

Dai Luru,

Zhao Jie,

Li Junbai

Publication year - 2014

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201402141

Subject(s) - photodynamic therapy , photosensitizer , mesoporous silica , cytotoxicity , peptide , nanoparticle , conjugated system , selectivity , chemistry , nanocomposite , in vitro , materials science , nanotechnology , mesoporous material , organic chemistry , biochemistry , catalysis , polymer

Peptide p160‐conjugated mesoporous silica nanoparticles (MSN) were fabricated and loaded with photosensitizer hypocrellin B (HB). The results indicate that the nanocomposites have better selectivity for cancer cells and higher cytotoxicity in photodynamic therapy in vitro. The nanocomposites can be used as a novel candidate in photodynamic therapy. This may be a general and promising method to modify nanoparticles to improve their cell affinity.

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