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Copper‐Catalyzed NH Insertion and Oxidative Aromatization Cascade: Facile Synthesis of 2‐Arylaminophenols
Author(s) -
Ding Dong,
Lv Xiaobing,
Li Jian,
Xu Guangyang,
Ma Bing,
Sun Jiangtao
Publication year - 2014
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201402080
Subject(s) - aromatization , carbazole , oxidative phosphorylation , cascade , catalysis , diazo , chemistry , copper , combinatorial chemistry , cascade reaction , organic chemistry , biochemistry , chromatography
A copper‐catalyzed cascade reaction of N‐H insertion and oxidative aromatization has been developed. 2‐Arylaminophenols have been prepared in moderate to high yields from the diazo substrates. Moreover, this newly established methodology allows efficient access to natural 1‐oxygenated carbazole alkaloids, such as glycozolicine and murrayafoline A.