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Base‐Catalyzed NN Bond Cleavage of Hydrazones: Synthesis of α‐Amino Ketones
Author(s) -
Tang HaiTao,
Zhou YunBing,
Zhu Yu,
Sun HongChao,
Lin Min,
Zhan ZhuangPing
Publication year - 2014
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201400037
Subject(s) - chemistry , cleavage (geology) , bond cleavage , catalysis , nucleophile , medicinal chemistry , nucleophilic substitution , condensation , stereochemistry , combinatorial chemistry , organic chemistry , materials science , fracture (geology) , composite material , physics , thermodynamics
An efficient Cs 2 CO 3 ‐promoted synthesis of α‐amino ketones using hydrazines, aldehydes, and α‐haloketones as starting materials through a cascade condensation/nucleophilic substitution/NN bond cleavage route is developed. The carbonyl group plays a key role in this novel NN bond cleavage process.
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