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Back Cover: A Multifunctional Bichromophoric Nanoaggregate for Fluorescence Imaging and Simultaneous Photogeneration of RNOS and ROS (Chem. Asian J. 11/2013)
Author(s) -
Fraix Aurore,
Gonçalves A. Ricardo,
Cardile Venera,
Graziano Adriana C. E.,
Theodossiou Theodossis A.,
Yannakopoulou Konstantina,
Sortino Salvatore
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201390042
Subject(s) - singlet oxygen , porphyrin , fluorescence , supramolecular chemistry , photodynamic therapy , nanotechnology , fluorescence lifetime imaging microscopy , chemistry , materials science , photochemistry , oxygen , optics , physics , organic chemistry , crystal structure , crystallography
Supramolecular Chemistry The fabrication of photoactivatable nanoconstructs of biomedical significance represents a challenging objective, in particular for multimodal imaging and therapy of cancer. In their Full Paper on page 2634 ff. , Salvatore Sortino et al. present a multifunctional supramolecular ensemble displaying imaging and multiple photototoxic modalities in a single nanostructure. The reported construct, which is based on a porphyrin–β–cyclodextrin conjugate, is internalized by living cells, can be easily imaged subcellularly by fluorescence microscopy, lacks any dark toxicity, and can release nitric oxide and singlet oxygen under under the exclusive control of visible‐light stimuli (see the image on the Back Cover).