Premium
Phosphine‐Initiated Domino Reaction: A Convenient Method for the Preparation of Spirocyclopentanones
Author(s) -
Liang Ling,
Li Erqing,
Xie Peizhong,
Huang You
Publication year - 2014
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201301641
Subject(s) - phosphine , annulation , domino , cascade reaction , combinatorial chemistry , chemistry , domino effect , reaction conditions , protocol (science) , quaternary carbon , catalysis , computer science , organic chemistry , physics , medicine , alternative medicine , pathology , enantioselective synthesis , nuclear physics
An efficient synthetic approach has been developed for the construction of the spirocyclopentanone skeleton via a phosphine‐catalyzed [3+2] annulation reaction. With this novel and economical protocol, various quaternary carbon‐centered spirocyclopentanones could be readily obtained.