Site‐Selective  CH Borylation  of Quinolines at the C8 Position Catalyzed by a Silica‐Supported Phosphane–Iridium System | Zendy

Konishi Shota | Zendy; Kawamorita Soichiro | Zendy; Iwai Tomohiro | Zendy; Steel Patrick G. | Zendy; Marder Todd B. | Zendy; Sawamura Masaya | Zendy

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Site‐Selective CH Borylation of Quinolines at the C8 Position Catalyzed by a Silica‐Supported Phosphane–Iridium System

Author(s) -

Konishi Shota,

Kawamorita Soichiro,

Iwai Tomohiro,

Steel Patrick G.,

Marder Todd B.,

Sawamura Masaya

Publication year - 2014

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201301423

Subject(s) - borylation , iridium , quinoline , chemistry , catalysis , ligand (biochemistry) , combinatorial chemistry , tetra , antagonist , stereochemistry , medicinal chemistry , organic chemistry , receptor , aryl , biochemistry , alkyl

Site‐selective CH borylation of quinoline derivatives at the C8 position has been achieved by using a heterogeneous Ir catalyst system based on a silica‐supported cage‐type monophosphane ligand SMAP. The efficient synthesis of a corticotropin‐releasing factor 1 (CRF 1 ) receptor antagonist based on a late‐stage CH borylation strategy demonstrates the utility of the C8 borylation reaction.

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