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Effective Cancer Cell Killing by Hydrophobic Nanovoid‐Enhanced Cavitation under Safe Low‐Energy Ultrasound
Author(s) -
Zhao Yang,
Zhu Yingchun,
Fu Jingke,
Wang Lianzhou
Publication year - 2014
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201301333
Subject(s) - ultrasound , cavitation , cancer cell , nanoparticle , biophysics , cancer , mesoporous silica , low energy , materials science , ultrasound energy , sonodynamic therapy , chemistry , nanotechnology , mesoporous material , chemical engineering , biochemistry , medicine , biology , catalysis , radiology , acoustics , physics , atomic physics , engineering
β‐Cyclodextrin (β‐CD)‐capped mesoporous silica nanoparticles with hydrophobic internal nanovoids were prepared and used for effective cancer cell killing in synergistic combination with low‐energy ultrasound (≤1.0 W cm −2 , 1 MHz). The water‐dispersible nanoparticles with hydrophobic internal nanovoids can be taken up by cancer cells and subsequently evoke a remarkable cavitation effect under irradiation with mild low‐energy ultrasound (≤1.0 W cm −2 , 1 MHz). A significant cancer cell killing effect was observed in cancer cells and in a mouse xenograft tumor model treated with the nanoagents together with the low‐energy ultrasound, showing a distinct dependence on the concentration of nanoagents and ultrasound intensity. By contrast, an antitumor effect was not observed when either low‐energy ultrasound or nanoagents were applied alone. These findings are significant as the technique promises a safe, low‐cost, and effective treatment for cancer therapy.