Premium
Synthesis of Quinazolines and Tetrahydroquinazolines: Copper‐Catalyzed Tandem Reactions of 2‐Bromobenzyl Bromides with Aldehydes and Aqueous Ammonia or Amines
Author(s) -
Fan Xuesen,
Li Bin,
Guo Shenghai,
Wang Yuanyuan,
Zhang Xinying
Publication year - 2014
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201301296
Subject(s) - tandem , chemistry , ammonia , catalysis , aqueous solution , copper , combinatorial chemistry , organic chemistry , materials science , composite material
An efficient synthesis of diversely substituted quinazolines and 1,2,3,4‐tetrahydroquinazolines through copper‐catalyzed tandem reactions of the readily available 2‐bromobenzyl bromides, aldehydes, and aqueous ammonia or amines has been developed. By using ammonia and simple aliphatic amines as the nitrogen source, the present method provides a versatile and practical protocol for the synthesis of quinazolines and 1,2,3,4‐tetrahydroquinazolines.