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Multifunctional Core–Shell Structured Nanocarriers for Synchronous Tumor Diagnosis and Treatment In Vivo
Author(s) -
Chen YinYin,
Ma PingAn,
Yang DongMei,
Wu Yuan,
Dai YunLu,
Li ChunXia,
Lin Jun
Publication year - 2014
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201301262
Subject(s) - nanomaterials , nanocarriers , materials science , surface modification , nanotechnology , mesoporous silica , biocompatibility , photon upconversion , polyethylene glycol , in vivo , nanoparticle , drug delivery , luminescence , nanocomposite , coating , peg ratio , mesoporous material , chemistry , optoelectronics , organic chemistry , catalysis , microbiology and biotechnology , finance , economics , metallurgy , biology
Multifunctional, mesoporous, silica‐coated upconversion luminescent/magnetic NaGdF 4 :Yb/Er@NaGdF 4 :Yb@mSiO 2 PEG (referred to as UCNPS; PEG=polyethylene glycol) nanocomposites were fabricated through a phase‐transfer‐assisted surfactant‐templating coating process , followed by hydrophilic polymer (PEG) functionalization to improve the stability and biocompatibility. The UCNP core imparts the nanomaterials with luminescence and magnetic properties for simultaneous upconversion optical and magnetic resonance (MR) imaging, whereas the mesoporous shell affords the nanomaterials the ability to load the anticancer drug doxorubicin. Proof‐of‐principle in vitro and in vivo experiments are presented to demonstrate that the resultant composite nanomaterials can serve as nanotheranostics for synchronous upconversion luminescence/MR dual modal imaging and anticancer drug delivery; this finally realizes the integration of diagnostics and the treatment of cancers.