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Synthesis of the Macrocyclic Core of Rhizopodin
Author(s) -
Song Liankai,
Liu Junyang,
Gui Honggang,
Hui Chunngai,
Zhou Jingjing,
Guo Yian,
Zhang Pengpeng,
Xu Zhengshuang,
Ye Tao
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201300802
Subject(s) - olefin metathesis , key (lock) , computer science , core (optical fiber) , information retrieval , combinatorial chemistry , metathesis , chemistry , organic chemistry , telecommunications , computer security , polymerization , polymer
Rhizing star : A stereoselective synthesis of the fully functionalized macrocyclic core of rhizopodin, a cytotoxic 38‐membered macrolide, has been disclosed. The key steps involve Sharpless epoxidation, Robinson–Gabriel oxazole synthesis, olefin cross‐metathesis, Suzuki coupling, Yamaguchi esterificationn, and Shiina macrolactonization.