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Facile Fabrication of Multi‐targeted and Stable Biochemical SERS Sensors
Author(s) -
Kim Hongki,
Kang Taejoon,
Lee Hyoban,
Ryoo Hyunseong,
Yoo Seung Min,
Lee Sang Yup,
Kim Bongsoo
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201300764
Subject(s) - substrate (aquarium) , materials science , nanotechnology , raman scattering , fabrication , nanowire , van der waals force , analyte , aptamer , selectivity , raman spectroscopy , sapphire , chemistry , molecule , chromatography , alternative medicine , laser , oceanography , pathology , optics , biology , genetics , biochemistry , catalysis , medicine , physics , organic chemistry , geology
The direct transfer of single‐crystalline Au nanowires (NWs) onto Au substrates was achieved by a simple attachment and detachment process. In the presence of a lubricant, Au NWs grown vertically on a sapphire substrate were efficiently moved to an Au substrate through van der Waals interactions. We demonstrate that the transferred Au NWs on the Au substrate can act as sensitive, reproducible, and long‐term‐stable surface‐enhanced Raman scattering (SERS) sensors by detecting human α‐thrombin as well as Pb 2+ and Hg 2+ ions. These three biochemically and/or environmentally important analytes were successfully detected with high sensitivity and selectivity by Au NW‐SERS sensors bound by a thrombin‐binding aptamer. Furthermore, the as‐prepared sensors remained in working order after being stored under ambient conditions at room temperature for 80 days. Because Au NWs can be routinely transferred onto Au substrates and because the resultant Au NW‐SERS sensors are highly stable and provide with high sensitivity and reproducibility of detection, these sensors hold potential for practical use in biochemical sensing.