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α‐Arylation, α‐Arylative Esterification , or Acylation : A Stoichiometry‐Dependent Trichotomy in the Pd‐Catalyzed Cross‐Coupling between Aldehydes and Aryl Bromides
Author(s) -
Nareddy Pradeep,
Mazet Clément
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201300724
Subject(s) - acylation , aryl , reagent , stoichiometry , catalysis , carbene , chemistry , trichotomy (philosophy) , organic chemistry , base (topology) , combinatorial chemistry , mathematics , alkyl , mathematical analysis , linguistics , philosophy
Three′s company : The selective α‐arylation and α‐arylative esterification of linear and branched aldehydes is reported for a variety of bromoarenes. The acylation of aryl bromides can be achieved with linear aldehydes (see scheme). All these transformations were performed with a single [(N‐heterocyclic carbene)Pd] catalyst through adjustment of the stoichiometry of the reagents and the appropriate base.