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Phosphine‐Catalyzed Rauhut–Currier Domino Reaction: A Facile Strategy for the Construction of Carbocyclic Spirooxindoles Skeletons
Author(s) -
Hu Chongchong,
Zhang Qinglong,
Huang You
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201300650
Subject(s) - domino , phosphine , catalysis , cascade reaction , chemistry , conjugated system , quaternary carbon , combinatorial chemistry , intermolecular force , organic chemistry , molecule , polymer , enantioselective synthesis
Push‐over : A novel domino reaction of activated conjugated dienes and methyleneindolinones incorporates a phosphine‐catalyzed intermolecular Rauhut–Currier to form two CC bonds and a quaternary carbon center. This method can be used to synthesize spirocyclopenteneoxindoles skeletons, which are potential building blocks for biologically active compounds.