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Asymmetric Transfer Hydrogenation of 3‐Nitroquinolines: Facile Access to Cyclic Nitro Compounds with Two Contiguous Stereocenters
Author(s) -
Cai XianFeng,
Chen MuWang,
Ye ZhiShi,
Guo RanNing,
Shi Lei,
Li YanQin,
Zhou YongGui
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201300380
Subject(s) - stereocenter , enantiopure drug , nitro , transfer hydrogenation , chemistry , combinatorial chemistry , stereochemistry , enantioselective synthesis , organic chemistry , catalysis , alkyl , ruthenium
Hi, neighbor! The first organocatalyzed asymmetric transfer hydrogenation of aromatic nitro compounds was successfully developed with up to 99 % ee. The new methodology provides a direct and facile access to enantiopure cyclic nitro compounds with two contiguous stereocenters.