Concise  Enantioselective Synthesis  of Cephalosporolide B, (4 R )‐4‐OMe‐Cephalosporolide C, and (4 S )‐4‐OMe‐Cephalosporolide C | Zendy

Ma Bin | Zendy; Zhong Zhuliang | Zendy; Hu Haitao | Zendy; Li Huilin | Zendy; Zhao Changgui | Zendy; Xie Xingang | Zendy; She Xuegong | Zendy

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Concise Enantioselective Synthesis of Cephalosporolide B, (4 R )‐4‐OMe‐Cephalosporolide C, and (4 S )‐4‐OMe‐Cephalosporolide C

Author(s) -

Ma Bin,

Zhong Zhuliang,

Hu Haitao,

Li Huilin,

Zhao Changgui,

Xie Xingang,

She Xuegong

Publication year - 2013

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201300332

Subject(s) - enantioselective synthesis , ring (chemistry) , yield (engineering) , ring closing metathesis , computer science , key (lock) , salt metathesis reaction , stereochemistry , metathesis , library science , chemistry , combinatorial chemistry , organic chemistry , physics , catalysis , operating system , thermodynamics , polymer , polymerization

Ring around the rosie : The effective enantioselective synthesis of the antimalarial nonenolide title compounds was achieved in a convergent strategy. Oxy‐Michael addition reaction was used to introduce the chiral methoxy group at C‐4, and ring‐closing metathesis (RCM) reaction (53 % yield) facilitated the key construction of the 10‐membered ring.

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