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Concise Enantioselective Synthesis of Cephalosporolide B, (4 R )‐4‐OMe‐Cephalosporolide C, and (4 S )‐4‐OMe‐Cephalosporolide C
Author(s) -
Ma Bin,
Zhong Zhuliang,
Hu Haitao,
Li Huilin,
Zhao Changgui,
Xie Xingang,
She Xuegong
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201300332
Subject(s) - enantioselective synthesis , ring (chemistry) , yield (engineering) , ring closing metathesis , computer science , key (lock) , salt metathesis reaction , stereochemistry , metathesis , library science , chemistry , combinatorial chemistry , organic chemistry , physics , catalysis , operating system , thermodynamics , polymer , polymerization
Ring around the rosie : The effective enantioselective synthesis of the antimalarial nonenolide title compounds was achieved in a convergent strategy. Oxy‐Michael addition reaction was used to introduce the chiral methoxy group at C‐4, and ring‐closing metathesis (RCM) reaction (53 % yield) facilitated the key construction of the 10‐membered ring.