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DDQ‐Induced Dehydrogenation of Heterocycles for CC Double Bond Formation: Synthesis of 2‐Thiazoles and 2‐Oxazoles
Author(s) -
Li Xiangnan,
Li Cheng,
Yin Bing,
Li Cong,
Liu Ping,
Li Jianli,
Shi Zhen
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201300267
Subject(s) - dehydrogenation , chemistry , double bond , bond , combinatorial chemistry , medicinal chemistry , organic chemistry , business , catalysis , finance
Strong as an Ox: 2‐Thiazoles and 2‐oxazoles are formed by oxidation of 2‐thiazolines and 2‐oxazolines without requiring substituents at the C4 and C5 positions. DDQ plays an important role as the oxidant in this transformation and metal is unnecessary. This general procedure shows good functional group tolerance and provides a wide variety of 2‐thiazoles and 2‐oxazoles in moderate to excellent yields.