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Oligonorbornenes with Hammock‐Like Crown Ether Pendants as Artificial Transmembrane Ion Channel
Author(s) -
Lin NaiTi,
Xie ChenYu,
Huang ShouLing,
Chen ChungHsuan,
Luh TienYau
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201300222
Subject(s) - crown ether , ether , phosphatidylcholine , polymer chemistry , counterion , oligomer , chemistry , liposome , membrane , ion , materials science , organic chemistry , biochemistry , phospholipid
Trimeric oligonorbornenes with hammock‐like crown ether pendants 3b and 3c were selectively synthesized by cascade metathetical cyclopolymerization upon treatment with the first generation Grubbs catalyst. These crown‐ether‐containing oligonorbornenes are impregnated in egg yolk phosphatidylcholine (EYPC) liposome as an artificial ion channel. The efficiency of the sodium ion transport properties has been examined. Oligomer 3c having a polar hydroxy end group exhibits the highest transport efficiency, which is comparable with the best efficiencies reported in literature. The orientation of the crown ether moieties in these oligomers may be critical for the ion transport properties.