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Highly Enantioselective Hydrogenation of 2,4‐Diaryl‐1,5‐Benzodiazepines Catalyzed by Dendritic Phosphinooxazoline Iridium Complexes
Author(s) -
Ma Baode,
Ding Ziyuan,
Liu Ji,
He Yanmei,
Fan QingHua
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201300150
Subject(s) - iridium , enantioselective synthesis , dendrimer , catalysis , reactivity (psychology) , diastereomer , combinatorial chemistry , chemistry , computer science , organic chemistry , medicine , alternative medicine , pathology
A PHOX with arms : A series of dendrimers with Ir phosphinooxazoline (PHOX) cores were designed and synthesized and found to be highly effective and recoverable catalysts for asymmetric hydrogenation of 2,4‐diaryl‐1,5‐benzodiazepines. An obvious positive dendritic effect on reactivity was observed, leading to chiral nitrogen‐containing heterocycles with excellent enantioselectivities.