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Enhanced Photodynamic Efficiency of an Aptamer‐Guided Fullerene Photosensitizer toward Tumor Cells
Author(s) -
Liu Qiaoling,
Xu Li,
Zhang Xuejie,
Li Nan,
Zheng Junpeng,
Guan Mirong,
Fang Xiaohong,
Wang Chunru,
Shu Chunying
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201300039
Subject(s) - photosensitizer , photodynamic therapy , aptamer , chemistry , biocompatibility , reactive oxygen species , biophysics , photochemistry , cancer research , biochemistry , microbiology and biotechnology , medicine , biology , organic chemistry
Fullerene‐based photosensitizers exhibit great potential in photodynamic therapy (PDT). Based on the high photodynamic efficacy of trimalonic acid‐modified C 70 fullerene (TF 70 ), we constructed an aptamer‐guided TF 70 photosensitizer and investigated its photodynamic effect. Conjugation of the novel aptamer (named R13) could effectively enhance the PDT efficiency of TF 70 against A549 lung cancer cells in the presence of serum. The lysosomal location of the TF 70 ‐R13 conjugate inside cells facilitates the production of intracellular reactive oxygen species (ROS), which can efficiently kill cells, under light irradiation. The enhanced photodynamic efficiency, along with its good biocompatibility in the dark, makes TF 70 ‐R13 a highly promising photosensitizer for tumor‐specific PDT.