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Cover Picture: Chiral‐Substrate‐Assisted Stereoselective Epoxidation Catalyzed by H 2 O 2 ‐Dependent Cytochrome P450 SPα (Chem. Asian J. 10/2012)
Author(s) -
Fujishiro Takashi,
Shoji Osami,
Kawakami Norifumi,
Watanabe Takahiro,
Sugimoto Hiroshi,
Shiro Yoshitsugu,
Watanabe Yoshihito
Publication year - 2012
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201290039
Subject(s) - enantioselective synthesis , chirality (physics) , chemistry , styrene , substrate (aquarium) , stereoselectivity , catalysis , styrene oxide , combinatorial chemistry , organic synthesis , organic chemistry , stereochemistry , chiral symmetry breaking , physics , polymer , oceanography , quantum mechanics , copolymer , quark , geology , nambu–jona lasinio model
Chiral substrate analogues assist in the enantioselective epoxidation of styrene catalyzed by H 2 O 2 ‐dependent cytochrome P450 SPα . In their Full Paper on page 2286 ff., Yoshihito Watanabe et al. report that the stereoselectivity of styrene oxide is largely affected by the chirality of the substrate analogues and that ( R )‐ibuprofen greatly enhances the formation of ( S )‐styrene oxide, thus showing that ibuprofen works as a chiral inducer. This unique strategy using the chiral substrate analogues allows for the alteration of the enantioselectivity of enzymes without any mutagenesis and thus contributes to the development of novel asymmetric biocatalysts.