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Synthesis of Functionalized Aryl Fluorides Using Organolithium Reagents in Flow Microreactors
Author(s) -
Nagaki Aiichiro,
Uesugi Yuki,
Kim Heejin,
Yoshida Junichi
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201201191
Subject(s) - aryl , lithium (medication) , reagent , electrophile , microreactor , steric effects , combinatorial chemistry , chemistry , computer science , flow chemistry , organic chemistry , psychology , catalysis , psychiatry , alkyl
Flow on : Flow microreactors enable the generation of aryl lithium compounds and subsequent electrophilic fluorination with NFSI and N ‐fluorosultam. The reaction can be successfully accomplished to synthesize various aryl fluorides involving an electron‐withdrawing, an electron‐donating, and a sterically hindered functional group in good yields.
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