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Tuning Catalysts to Tune the Products: Phosphine‐Catalyzed Aza‐Michael Addition Reaction of Hydrazones with Allenoates
Author(s) -
Li Erqing,
Xie Peizhong,
Yang Lihua,
Liang Ling,
Huang You
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201201087
Subject(s) - michael reaction , phosphine , catalysis , chemistry , organic chemistry , combinatorial chemistry
A new tunable phosphine‐catalyzed aza‐Michael β‐addition reaction between allenoates and various hydrazones has been developed. These reactions are most‐efficiently promoted by a catalytic amount of phosphine catalysts. These atom‐economical reactions are operationally simple and their corresponding adducts can been achieved in high yields and high selectivity under mild reaction conditions. Further studies revealed that different phosphine catalyst can produce different adducts from the same starting materials.