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Iron‐Catalyzed Synthesis of 2‐Vinylquinolines via sp 3 CH Functionalization and Subsequent CN Cleavage
Author(s) -
Li Yunfeng,
Guo Fengfeng,
Zha Zhenggen,
Wang Zhiyong
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201201039
Subject(s) - cleavage (geology) , surface modification , catalysis , chemistry , combinatorial chemistry , computer science , organic chemistry , materials science , fracture (geology) , composite material
Synthesize while the iron is hot : The synthesis of 2‐vinylquinolines via a FeCl 3 ‐catalyzed CH sp 3 functionalization and a subsequent CN cleavage is reported. The method is simple and efficient, and avoids the use of organometallic compounds. A variety of 2‐vinylquinolines were obtained from readily available 2‐methylquinolines with moderate to good yields.