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Ultra‐small, Uniform, and Single bcc‐Phased Fe x Co 1‐x /Graphitic Shell Nanocrystals for T 1 Magnetic Resonance Imaging Contrast Agents
Author(s) -
Choi In Ae,
Li Yan,
Kim Da Jeong,
Pal Mou,
Cho JeeHyun,
Lee Kyujoon,
Jung MyungHwa,
Lee Chulhyun,
Seo Won Seok
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201200950
Subject(s) - nanocrystal , superparamagnetism , materials science , thermal decomposition , analytical chemistry (journal) , metal , transition metal , carbon fibers , crystallography , nanotechnology , chemistry , magnetization , metallurgy , organic chemistry , physics , quantum mechanics , composite number , magnetic field , composite material , catalysis
We have synthesized ultra‐small and uniform Fe x Co 1‐x /graphitic carbon shell (Fe x Co 1‐x /GC) nanocrystals (x=0.13, 0.36, 0.42, 0.50, 0.56, and 0.62, respectively) with average diameters of <4 nm by thermal decomposition of metal precursors in approximately 60 nm MCM‐41 and methane CVD. The composition of the Fe x Co 1‐x /GC nanocrystals can be tuned by changing the Fe:Co ratios of the metal precursors. The Fe x Co 1‐x /GC nanocrystals show superparamagnetic properties at room temperature. The Fe 0.50 Co 0.50 /GC, Fe 0.56 Co 0.44 /GC, and Fe 0.62 Co 0.38 /GC nanocrystals have a single bcc FeCo structure, whereas the Fe 0.13 Co 0.87 /GC, Fe 0.36 Co 0.64 /GC, and Fe 0.42 Co 0.58 /GC nanocrystals have a mixed structure of bcc FeCo and fcc Co. The single bcc‐phased Fe x Co 1‐x /GC nanocrystals functionalized with phospholipid–poly(ethylene glycol) (PL–PEG) in phosphate buffered saline (PBS) are demonstrated to be excellent T 1 MRI contrast agents.