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Mono‐PEGylated Zinc(II) Phthalocyanines: Preparation, Nanoparticle Formation, and In Vitro Photodynamic Activity
Author(s) -
Zhao Baozhong,
Duan Wubiao,
Lo PuiChi,
Duan Lei,
Wu Chi,
Ng Dennis K. P.
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201200897
Subject(s) - singlet oxygen , photodynamic therapy , zinc , nanoparticle , in vitro , aqueous medium , aqueous solution , chemistry , photochemistry , materials science , nuclear chemistry , nanotechnology , oxygen , organic chemistry , biochemistry
PEGged! A series of mono‐PEGylated zinc(II) phthalocyanines for photodynamic therapy with singlet oxygen have been prepared and formulated in aqueous media with different methods. The system based on silica nanoparticles exhibits remarkably high stability and in vitro photocytotoxicity.