Premium
Molecular Recognition of Zwitterions: Enhanced Binding and Selective Recognition of Miltefosine by a Squaramide‐Based Host
Author(s) -
López Carlos,
Sanna Elena,
Carreras Lucas,
Vega Manel,
Rotger Carmen,
Costa Antoni
Publication year - 2013
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201200881
Subject(s) - squaramide , miltefosine , host (biology) , computer science , service (business) , chemistry , combinatorial chemistry , world wide web , biology , business , biochemistry , genetics , organocatalysis , enantioselective synthesis , catalysis , parasite hosting , marketing , leishmania
The importance of a synergic combination between electrostatic and hydrogen‐bonding interactions has been demonstrated. A self‐complementary amidosquarate‐squaramide host for miltefosine has been disclosed. In DMSO, this rather structurally simple host exhibits high affinity and enhanced selectivity for miltefosine owing to the goal‐keeping effect of the amidosquarate unit.