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Enantioselective Addition of Dialkylzincs to Aldehydes Catalyzed by (−)‐MITH
Author(s) -
Cheng YingNi,
Wu HsyuehLiang,
Wu PingYu,
Shen YingYing,
Uang BiingJiun
Publication year - 2012
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201200676
Subject(s) - enantioselective synthesis , catalysis , camphor , optically active , chemistry , chiral ligand , alkylation , organic chemistry , ligand (biochemistry) , biochemistry , receptor
Abstract An effective catalytic system that imparts high enantioselectivity has been disclosed for the synthesis of optically active alcohols, which may undergo further chemical transformations. The enantioselective alkylation of aldehydes with dialkylzincs to afford the corresponding optically active alcohols with excellent enantioselectvities has been achieved in the presence of 0.1–0.5 mol % of the camphor‐derived chiral ligand (−)‐2‐ exo ‐morpholinoisobornane‐10‐thiol (MITH) ( 1 ) at room temperature or at 0 °C.