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Stereoselective Glycosylation of Glucosamine: The Role of the N ‐Protecting Group
Author(s) -
Enugala Ramu,
Carvalho Luísa C. R.,
Dias Pires Marina J.,
Marques M. Manuel B.
Publication year - 2012
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201200338
Subject(s) - glycoconjugate , glycosylation , glucosamine , stereoselectivity , amine gas treating , chemistry , protecting group , biocompatible material , biochemistry , combinatorial chemistry , medicine , organic chemistry , catalysis , alkyl , biomedical engineering
Oligosaccharides and glycoconjugates play an important role in biological processes. The use of these complex polymers as biocompatible materials for medicinal applications as well as therapeutic agents for the treatment of several diseases has attracted considerable interest. However, these investigations require large and pure amounts of glycostructures. Glucosamine is one of the major building blocks of these highly important glycoconjugates. Recently, considerable synthetic efforts have been devoted to improving stereoselective glycosylation . In this Focus review, the role of the amine protecting group in the outcome of the glucosamine glycosylation reaction is highlighted.