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1‐Bromo‐2‐(cyclopropylidenemethyl)benzene: A Useful Building Block in the Palladium‐Catalyzed Reaction of 2‐Alkynylbenzenamine
Author(s) -
Li Shaoyu,
Luo Yong,
Wang Xiaocong,
Guo Minjie,
Wu Jie
Publication year - 2012
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201200122
Subject(s) - palladium , regioselectivity , benzene , phosphine , catalysis , domino , chemistry , medicinal chemistry , carbene , cascade reaction , combinatorial chemistry , block (permutation group theory) , organic chemistry , mathematics , geometry
A novel palladium‐catalyzed domino reaction of 1‐bromo‐2‐(cyclopropylidenemethyl)benzene and 2‐alkynylbenzenamine is reported, which generates 2‐(naphthalen‐2‐yl)benzenamines and 5 H ‐indeno[1,2‐ c ]quinolines via 6‐ endo and 5‐ exo cyclization, respectively. The regioselectivity for the final outcome can be affected by phosphine and N‐heterocyclic carbene ligands.