1‐Bromo‐2‐(cyclopropylidenemethyl)benzene: A Useful Building Block in the Palladium‐Catalyzed Reaction of 2‐Alkynylbenzenamine | Zendy

Li Shaoyu | Zendy; Luo Yong | Zendy; Wang Xiaocong | Zendy; Guo Minjie | Zendy; Wu Jie | Zendy

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1‐Bromo‐2‐(cyclopropylidenemethyl)benzene: A Useful Building Block in the Palladium‐Catalyzed Reaction of 2‐Alkynylbenzenamine

Author(s) -

Li Shaoyu,

Luo Yong,

Wang Xiaocong,

Guo Minjie,

Wu Jie

Publication year - 2012

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201200122

Subject(s) - palladium , regioselectivity , benzene , phosphine , catalysis , domino , chemistry , medicinal chemistry , carbene , cascade reaction , combinatorial chemistry , block (permutation group theory) , organic chemistry , mathematics , geometry

A novel palladium‐catalyzed domino reaction of 1‐bromo‐2‐(cyclopropylidenemethyl)benzene and 2‐alkynylbenzenamine is reported, which generates 2‐(naphthalen‐2‐yl)benzenamines and 5 H ‐indeno[1,2‐ c ]quinolines via 6‐ endo and 5‐ exo cyclization, respectively. The regioselectivity for the final outcome can be affected by phosphine and N‐heterocyclic carbene ligands.

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